Radiation damage to DNA in DNA-protein complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F11%3A00361467" target="_blank" >RIV/61389005:_____/11:00361467 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.02.003" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2011.02.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.02.003" target="_blank" >10.1016/j.mrfmmm.2011.02.003</a>
Alternative languages
Result language
angličtina
Original language name
Radiation damage to DNA in DNA-protein complexes
Original language description
The most aggressive product of water radiolysis, the hydroxyl (OH) radical, is responsible for the indirect effect of ionizing radiations on DNA in solution and aerobic conditions. Monte-Carlo based model RADACK, allows calculating the relative probability of damage of each nucleotide of DNA irradiated alone or in complexes with proteins. The confrontation of the calculated values with the results of the radiolytic footprinting experiments together with molecular modeling calculations show that: (1) theextent and location of the lesions are strongly dependent on the structure of DNA, which in turns is modulated by the base sequence and by the binding of proteins and (2) the regions in contact with the protein can be protected against the attack by thehydroxyl radicals via masking of the binding site and by scavenging of the radicals.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
ISSN
0027-5107
e-ISSN
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Volume of the periodical
711
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
41-48
UT code for WoS article
000291914700005
EID of the result in the Scopus database
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