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Radiation damage to DNA in DNA-protein complexes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F11%3A00361467" target="_blank" >RIV/61389005:_____/11:00361467 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.02.003" target="_blank" >http://dx.doi.org/10.1016/j.mrfmmm.2011.02.003</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.mrfmmm.2011.02.003" target="_blank" >10.1016/j.mrfmmm.2011.02.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Radiation damage to DNA in DNA-protein complexes

  • Original language description

    The most aggressive product of water radiolysis, the hydroxyl (OH) radical, is responsible for the indirect effect of ionizing radiations on DNA in solution and aerobic conditions. Monte-Carlo based model RADACK, allows calculating the relative probability of damage of each nucleotide of DNA irradiated alone or in complexes with proteins. The confrontation of the calculated values with the results of the radiolytic footprinting experiments together with molecular modeling calculations show that: (1) theextent and location of the lesions are strongly dependent on the structure of DNA, which in turns is modulated by the base sequence and by the binding of proteins and (2) the regions in contact with the protein can be protected against the attack by thehydroxyl radicals via masking of the binding site and by scavenging of the radicals.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

  • ISSN

    0027-5107

  • e-ISSN

  • Volume of the periodical

    711

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    41-48

  • UT code for WoS article

    000291914700005

  • EID of the result in the Scopus database