Radiation damage to DNA-protein complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F11%3A00361498" target="_blank" >RIV/61389005:_____/11:00361498 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1088/1742-6596/261/1/012010" target="_blank" >http://dx.doi.org/10.1088/1742-6596/261/1/012010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1742-6596/261/1/012010" target="_blank" >10.1088/1742-6596/261/1/012010</a>

Result language
angličtina
Original language name
Radiation damage to DNA-protein complexes
Original language description
We review here the advances in understanding the effects of ionizing radiations on DNA, proteins and their complexes. A model of simulation of the reaction of these radicals with the macromolecules (called RADACK) was developed and was used for calculating the probabilities of damage of each constituent of DNA or proteins (nucleotide or amino-acid). The calculations allowed to draw conclusions from electrophoresis, mutagenesis, spectroscopic (fluorescence, circular dichroism) and mass spectrometry experiments. Thus we have shown that the extent and location of the lesions are strongly dependent on the 3D structure of the macromolecules, which in turns is modulated by their sequence and by the binding of some ligands.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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