Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F12%3A00380755" target="_blank" >RIV/61389005:_____/12:00380755 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00411-012-0417-x" target="_blank" >http://dx.doi.org/10.1007/s00411-012-0417-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00411-012-0417-x" target="_blank" >10.1007/s00411-012-0417-x</a>

Result language
angličtina
Original language name
Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles
Original language description
The purpose of this study was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays. Whole blood collected from one donor was exposed to different doses of alpha particles (Am-241), X-rays and a combination of both. Micronuclei (MN) in binucleated PBL were scored as the endpoint. Moreover, the size of MN was measured. The results show that exposure of PBL to a mixed beam of high and low linear energy transfer radiation led tosignificantly higher than expected frequencies of MN. The measurement of MN size did not reveal any differences between the effect of alpha particles and mixed beam. In conclusion, a combined exposure of PBL to alpha particles and X-rays leads to a synergistic effect as measured by the frequency of MN. From the analysis of MN distributions, we conclude that the increase was due to an impaired repair of X-ray-induced DNA damage.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)