Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F12%3A00385635" target="_blank" >RIV/61389005:_____/12:00385635 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/rpd/ncs024" target="_blank" >http://dx.doi.org/10.1093/rpd/ncs024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncs024" target="_blank" >10.1093/rpd/ncs024</a>

Result language

angličtina

Original language name

Characterisation of a setup for mixed beam exposures of cells to Am-241 alpha particles and X-rays

Original language description

Exposure of humans to mixed fields of high- and low-linear energy transfer (LET) radiation occurs in many situations. From the perspective of health risk associated with exposure to mixed fields, it is important to understand the interactions between different radiation types. In most cellular investigations on mixed beams, two types of irradiations have been applied sequentially. Simultaneous irradiation is the desirable scenario but requires a dedicated irradiation facility. The authors have constructed a facility where cells can be simultaneously exposed to Am-241 alpha particles and 190-kV X-rays at 37C. This study presents the technical details and the dosimetry of the setup, as well as validates the performance of the setup for clonogenic survival in AA8 Chinese hamster ovary cells. No significant synergistic effect was observed. The relative biological effectiveness of the alpha particles was 2.56 for 37 and 1.90 for 10 clonogenic survival.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BG - Nuclear, atomic and molecular physics, accelerators

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

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Volume of the periodical

151

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

570-579

UT code for WoS article

000308960900023

EID of the result in the Scopus database

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