Heterochromatinization associated with cell differentiation as a model to study DNA double strand break induction and repair in the context of higher-order chromatin structure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F14%3A00424731" target="_blank" >RIV/61389005:_____/14:00424731 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/14:00424731 RIV/60461373:22330/14:43897894
Result on the web
<a href="http://dx.doi.org/10.1016/j.apradiso.2013.01.029" target="_blank" >http://dx.doi.org/10.1016/j.apradiso.2013.01.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apradiso.2013.01.029" target="_blank" >10.1016/j.apradiso.2013.01.029</a>
Alternative languages
Result language
angličtina
Original language name
Heterochromatinization associated with cell differentiation as a model to study DNA double strand break induction and repair in the context of higher-order chromatin structure
Original language description
Cell differentiation is associated with extensive gene silencing, heterochromatinization and potentially decreasing need for repairing DNA double-strand breaks (DSBs). Differentiation stages of blood cells thus represent an excellent model to study DSB induction, repair and misrepair in the context of changing higher-order chromatin structure. We show that immature granulocytes form gamma H2AX and 53BP1 foci, contrary to the mature cells; however, these foci colocalize only rarely and DSB repair is inefficient. Moreover, specific chromatin structure of granulocytes probably influences DSB induction. (C) 2013 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LD12039" target="_blank" >LD12039: The influence of higher-order chromatin structure on the mechanism of DNA double-strand break (DSB) repair and formation of chromosomal translocations in cells irradiated with gamma rays and medically relevant ion beams</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Applied Radiation and Isotopes
ISSN
0969-8043
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
Jan
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
177-185
UT code for WoS article
000329539900020
EID of the result in the Scopus database
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