Dose-dependent micronuclei formation in normal human fibroblasts exposed to proton radiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F15%3A00448253" target="_blank" >RIV/61389005:_____/15:00448253 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00411-015-0598-1" target="_blank" >http://dx.doi.org/10.1007/s00411-015-0598-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00411-015-0598-1" target="_blank" >10.1007/s00411-015-0598-1</a>

Result language

angličtina

Original language name

Dose-dependent micronuclei formation in normal human fibroblasts exposed to proton radiation

Original language description

Micronuclei are small extranuclear bodies resulting from chromosome fragments or the whole chromosomes secluded from daughter nuclei during mitosis. The number of radiation-induced micronuclei reflects the level of chromosomal damage and relates to an absorbed dose and quality of incident ionizing radiation. The aim of the present study was to determine the micronucleus formation as a specific biological marker for acute radiation-induced DNA damage in normal human fibroblasts exposed to 30-MeV protonsand Co-60 gamma radiation. We found a linear increase in binuclear cells containing micronuclei for absorbed doses from 1 to 5 Gy for both radiation modalities. However, the total number of micronuclei in binuclear cells follows a linear-quadratic dose dependence. In case of human exposure to mixed radiation fields or high LET radiation, the proportion of binuclear cells containing micronuclei from all binuclear cells can thus serve as a good biomarker of radiation-induced DNA damage.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation and Environmental Biophysics

ISSN

0301-634X

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

327-334

UT code for WoS article

000358328800008

EID of the result in the Scopus database

2-s2.0-84938992372