Molecular Radiation Biology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00601476" target="_blank" >RIV/68081707:_____/23:00601476 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/book/10.1007/978-3-031-18810-7" target="_blank" >https://link.springer.com/book/10.1007/978-3-031-18810-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-18810-7_3" target="_blank" >10.1007/978-3-031-18810-7_3</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Radiation Biology
Original language description
Chapter Objectives • To gain familiarity with biomolecules that undergo radiolysis after ionizing radiation (IR) and to learn about some of the damaged products and the expected biological consequences • To understand how IR influences various DNA repair mechanisms, cell cycle phases, and cell death mechanisms as well as associated signaling cascades that are involved • To get knowledge on higher order chromatin organization and its connection to DNA damage repair • To be able to distinguish between cell survival and cell viability and understand different in vitro and in vivo assays used to evaluate clonogenic capacity • To understand chromosomal aberrations including chromosomal translocations in different cell cycle phases, formation of micronuclei, radiation-induced foci, and their dependence on the type of the incidental radiation as well as to acknowledge the health risks of such cellular damages • To get familiar with mechanisms of oxidative stress, telomeres/senescence, and immunity in the context of cancer biology and/or radiation response • To get acquainted with the types and underlying mechanisms of cellular hyper-radiosensitivity • To describe how radiation resistance can be induced by external factors such as hypoxia and previous low-dose exposure or as part of the tumor cell evolution • To get knowledge on the role of epigenetic factors, e.g., various types of RNAs, extracellular vesicles, as well as DNA methylation, histone modification, and gene expression in the cellular radiation response • To define signatures of radiation response comprised of changes at gene transcription level and their biological consequences • To become acquainted with CRISPR-CAS9 genome editing system and its application in molecular biology science as well as in DNA DSB repair analyses
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Radiobiology Textbook
ISBN
978-3-031-18809-1
Number of pages of the result
107
Pages from-to
83-189
Number of pages of the book
687
Publisher name
Springer
Place of publication
Švýcarsko
UT code for WoS chapter
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