DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F11%3A00002580" target="_blank" >RIV/60162694:G44__/11:00002580 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/11:10105714
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/60/60_667.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/60/60_667.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
DNA damage caused by ionizing radiation in embryonic diploid fibroblasts WI-38 induces both apoptosis and senescence
Original language description
Cellular response to ionizing radiation-induced damage depends on the cell type and the ability to repair DNA damage. Some types of cells undergo apoptosis, whereas others induce a permanent cell cycle arrest and do not proliferate. Our study demonstrates two types of response of embryonic diploid fibroblasts WI-38 to ionizing radiation. In the WI-38 cells p53 is activated, protein p21 increases, but the cells are arrested in G2 phase of cell cycle. Some of the cells die by apoptosis, but in remaining viable cells p16 increases, senescence associated DNA damage foci occur, and senescence-associated beta-galactosidase activity increases, which indicate stress-induced premature senescence.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
<a href="/en/project/GA304%2F09%2F1568" target="_blank" >GA304/09/1568: Chatacteristic of resistance of adult stem cells to genotoxic stress</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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