Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F17%3A00477333" target="_blank" >RIV/61389005:_____/17:00477333 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/17:00319443

Result on the web

<a href="http://dx.doi.org/10.1007/s13246-017-0540-8" target="_blank" >http://dx.doi.org/10.1007/s13246-017-0540-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13246-017-0540-8" target="_blank" >10.1007/s13246-017-0540-8</a>

Result language

angličtina

Original language name

Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode

Original language description

In recent years, there is an increased interest in using scanning modes in proton therapy, due to the more conformal dose distributions, thanks to the spot-weighted dose delivery. The dose rate in each spot is however much higher than the dose rate when using passive irradiation modes, which could affect the cell response. The purpose of this work was to investigate how the relative biological effectiveness changes along the spread-out Bragg peak created by protons delivered by the pencil beam scanning mode. Cell survival and micronuclei formation were investigated in four positions along the spread-out Bragg peak for various doses. Monte Carlo simulations were used to estimate the dose-averaged linear energy transfer values in the irradiation positions. The cell survival was found to decrease the deeper the sample was placed in the spread-out Bragg peak, which corresponds to the higher linear energy transfer values found using Monte Carlo simulations. The micronuclei frequencies indicate more complex cell injuries at that distal position compared to the proximal part of the spread-out Bragg peak. The relative biological effectiveness determined in this study varies significantly and systematically from 1.1, which is recommended value by the International Commission on Radiation Units, in all the studied positions. In the distal position of spread-out Bragg peak the relative biological effectiveness values were found to be 2.05 +/- 0.44, 1.85 +/- 0.42, 1.53 +/- 0.38 for survival levels 90, 50 and 10%, respectively.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10304 - Nuclear physics

Project

<a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE

ISSN

0158-9938

e-ISSN

—

Volume of the periodical

40

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

359-368

UT code for WoS article

000404137700011

EID of the result in the Scopus database

2-s2.0-85015638385