In Vitro Comparison of Passive and Active Clinical Proton Beams

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00539168" target="_blank" >RIV/68378050:_____/20:00539168 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/1422-0067/21/16/5650" target="_blank" >https://www.mdpi.com/1422-0067/21/16/5650</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms21165650" target="_blank" >10.3390/ijms21165650</a>

Result language

angličtina

Original language name

In Vitro Comparison of Passive and Active Clinical Proton Beams

Original language description

Nowadays, the irradiation methodology in proton therapy is switching from the use of passively scattered beams to active pencil beams due to the possibility of more conformal dose distributions. The dose rates of active pencil beams are much higher than those of passive beams. The purpose of this study was to investigate whether there is any difference in the biological effectiveness of these passive and active irradiation modes. The beam qualities of double scattering and pencil beam scanning were measured dosimetrically and simulated using the Monte Carlo code. Using the medulloblastoma cell line DAOY, we performed an in vitro comparison of the two modes in two positions along the dose-deposition curve plateau and inside the Bragg peak. We followed the clonogenic cell survival, apoptosis, micronuclei, and gamma H2AX assays as biological endpoints. The Monte Carlo simulations did not reveal any difference between the beam qualities of the two modes. Furthermore, we did not observe any statistically significant difference between the two modes in the in vitro comparison of any of the examined biological endpoints. Our results do not show any biologically relevant differences related to the different dose rates of passive and active proton beams.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/LM2015063" target="_blank" >LM2015063: National Infrastructure for Chemical Biology</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

16

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

5650

UT code for WoS article

000565090200001

EID of the result in the Scopus database

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