Dosimetry as a Catch in Radiobiology Experiments

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F18%3A00494791" target="_blank" >RIV/61389005:_____/18:00494791 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/18:00326315

Result on the web

<a href="http://dx.doi.org/10.1667/RR15020.1" target="_blank" >http://dx.doi.org/10.1667/RR15020.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1667/RR15020.1" target="_blank" >10.1667/RR15020.1</a>

Result language

angličtina

Original language name

Dosimetry as a Catch in Radiobiology Experiments

Original language description

Experimental radiobiological studies in which the effects of ionizing radiation on a biological model are examined often highlight the biological aspects while missing detailed descriptions of the geometry, sample and dosimetric methods used. Such omissions can hinder the reproducibility and comparability of the experimental data. An application based on the Geant4 simulation toolkit was developed to design experiments using a biological solution placed in a microtube. The application was used to demonstrate the influence of the type of microtube, sample volume and energy of a proton source on the dose distribution across the sample, and on the mean dose in the whole sample. The results shown here are for samples represented by liquid water in the 0.4-, 1.5- and 2.0-ml microtubes irradiated with 20, 30 and 100 MeV proton beams. The results of this work demonstrate that the mean dose and homogeneity of the dose distribution within the sample strongly depend on all three parameters. Furthermore, this work shows how the dose uncertainty propagates into the scored primary DNA damages in plasmid DNA studies using agarase gel electrophoresis. This application is provided freely to assist users in verifying their experimental setup prior to the experiment.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

<a href="/en/project/GJ17-03403Y" target="_blank" >GJ17-03403Y: Links between radiation track structure and clustered DNA damage</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Research

ISSN

0033-7587

e-ISSN

—

Volume of the periodical

190

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

404-411

UT code for WoS article

000446180500007

EID of the result in the Scopus database

2-s2.0-85054417324