Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F22%3A00560656" target="_blank" >RIV/61389005:_____/22:00560656 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21340/22:00359662
Result on the web
<a href="https://doi.org/10.1093/rpd/ncac093" target="_blank" >https://doi.org/10.1093/rpd/ncac093</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/rpd/ncac093" target="_blank" >10.1093/rpd/ncac093</a>
Alternative languages
Result language
angličtina
Original language name
Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism
Original language description
Proton radiotherapy for the treatment of cancer offers an excellent dose distribution. Cellular experiments have shown that in terms of biological effects, the sharp dose distribution is further amplified, by as much as 75%, in the presence of boron. It is a matter of debate whether the underlying physical processes involve the nuclear reaction of B-11 with protons or B-10 with secondary neutrons, both producing densely ionizing short-ranged particles. Likewise, potential roles of intercellular communication or boron acting as a radiosensitizer are not clear. We present an ongoing research project based on a multiscale approach to elucidate the mechanism by which boron enhances the effectiveness of proton irradiation in the Bragg peak. It combines experimental with simulation tools to study the physics of proton-boron interactions, and to analyze intra- and inter-cellular boron biology upon proton irradiation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GA21-06451S" target="_blank" >GA21-06451S: Puzzling enhancement of proton-induced cellular damage by boron</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiation Protection Dosimetry
ISSN
0144-8420
e-ISSN
1742-3406
Volume of the periodical
198
Issue of the periodical within the volume
9-11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
527-531
UT code for WoS article
000844405700006
EID of the result in the Scopus database
2-s2.0-85160074082