Improving the design of ion track-based biosensors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F18%3A00495562" target="_blank" >RIV/61389005:_____/18:00495562 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/978-94-024-1304-5_14" target="_blank" >http://dx.doi.org/10.1007/978-94-024-1304-5_14</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-94-024-1304-5_14" target="_blank" >10.1007/978-94-024-1304-5_14</a>

Result language

angličtina

Original language name

Improving the design of ion track-based biosensors

Original language description

In the last decade we had developed new types of biosensors, by cladding the inner walls of transparent etched swift heavy ion tracks in thin polymer foils with enzymes. The enzymatic reaction products of appropriate analytes penetrating into narrow tracks are enriched in the track’s confinement, and they change the electrical track properties if their charge states differ from those of the analytes. It was yet unknown how to design these sensors so that their best efficiency and highest possible sensitivity is achieved. This requires the accurate knowledge of the optimum track radius and the degree of product enrichment within the tracks. These questions were answered by appropriate experiments described here. The above studies restricted to transparent tracks only. After it became evident that also thin membranes can be formed within such tracks – thus separating transparent tracks into two adjacent semi-transparent segments each – we were curious in how far such structures might also become useful as sensors. In fact, two promising approaches emerged, one that uses these structures as polarization-induced capacitive biosensors, and another one that considers the semitransparent track segments as neighboring “electrostatic bottles” which can be discharged by pulse-wise product emission. Preliminary results indicate that the latter sensor type is superior in its performance to all other ones.

Czech name

—

Czech description

—

Type

C - Chapter in a specialist book

CEP classification

—

OECD FORD branch

10610 - Biophysics

Project

<a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

NATO Science for Peace and Security Series A: Chemistry and Biology

ISBN

978-94-024-1303-8

Number of pages of the result

13

Pages from-to

185-197

Number of pages of the book

352

Publisher name

Springer Nature Switzerland AG

Place of publication

Cham

UT code for WoS chapter

—