Analytical formulas representing track-structure simulations on DNA damage induced by protons and light ions at radiotherapy-relevant energies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F20%3A00534247" target="_blank" >RIV/61389005:_____/20:00534247 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41598-020-72857-z" target="_blank" >https://doi.org/10.1038/s41598-020-72857-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-020-72857-z" target="_blank" >10.1038/s41598-020-72857-z</a>
Alternative languages
Result language
angličtina
Original language name
Analytical formulas representing track-structure simulations on DNA damage induced by protons and light ions at radiotherapy-relevant energies
Original language description
Track structure based simulations valuably complement experimental research on biological effects of ionizing radiation. They provide information at the highest level of detail on initial DNA damage induced by diverse types of radiation. Simulations with the biophysical Monte Carlo code PARTRAC have been used for testing working hypotheses on radiation action mechanisms, for benchmarking other damage codes and as input for modelling subsequent biological processes. To facilitate such applications and in particular to enable extending the simulations to mixed radiation field conditions, we present analytical formulas that capture PARTRAC simulation results on DNA single- and double-strand breaks and their clusters induced in cells irradiated by ions ranging from hydrogen to neon at energies from 0.5 GeV/u down to their stopping. These functions offer a means by which radiation transport codes at the macroscopic scale could easily be extended to predict biological effects, exploiting a large database of results from micro-/nanoscale simulations, without having to deal with the coupling of spatial scales and running full track-structure calculations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
15775
UT code for WoS article
000577252400006
EID of the result in the Scopus database
2-s2.0-85091408049