Potential morbidity reduction for lung stereotactic body radiation therapy using respiratory gating
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F21%3A00549521" target="_blank" >RIV/61389005:_____/21:00549521 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3390/cancers13205092" target="_blank" >https://doi.org/10.3390/cancers13205092</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers13205092" target="_blank" >10.3390/cancers13205092</a>
Alternative languages
Result language
angličtina
Original language name
Potential morbidity reduction for lung stereotactic body radiation therapy using respiratory gating
Original language description
We investigated the potential of respiratory gating to mitigate the motion-caused misdos-age in lung stereotactic body radiotherapy (SBRT). For fourteen patients with lung tumors, we investigated treatment plans for a gating window (GW) including three breathing phases around the maximum exhalation phase, GW40-60. For a subset of six patients, we also assessed a preceding three-phase GW20-40 and six-phase GW20-70. We analyzed the target volume, lung, esophagus, and heart doses. Using normal tissue complication probability (NTCP) models, we estimated radiation pneumonitis and esophagitis risks. Compared to plans without gating, GW40-60 significantly reduced doses to organs at risk without impairing the tumor doses. On average, the mean lung dose decreased by 0.6 Gy (p < 0.001), treated lung V20Gy by 2.4% (p = 0.003), esophageal dose to 5cc by 2.0 Gy (p = 0.003), and maximum heart dose by 3.2 Gy (p = 0.009). The model-estimated mean risks of 11% for pneumonitis and 12% for esophagitis without gating decreased upon GW40-60 to 7% and 9%, respectively. For the highest-risk patient, gating reduced the pneumonitis risk from 43% to 32%. Gating is most beneficial for patients with high-toxicity risks. Pre-treatment toxicity risk assessment may help optimize patient selection for gating, as well as GW selection for individual patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancers (Basel)
ISSN
2072-6694
e-ISSN
2072-6694
Volume of the periodical
13
Issue of the periodical within the volume
20
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
5092
UT code for WoS article
000747117100001
EID of the result in the Scopus database
2-s2.0-85116881103