First independent validation of the proton-boron capture therapy concept

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F24%3A00598030" target="_blank" >RIV/61389005:_____/24:00598030 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21340/24:00380584 RIV/00064190:_____/24:10001315
Result on the web
<a href="https://doi.org/10.1038/s41598-024-69370-y" target="_blank" >https://doi.org/10.1038/s41598-024-69370-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-69370-y" target="_blank" >10.1038/s41598-024-69370-y</a>

Result language
angličtina
Original language name
First independent validation of the proton-boron capture therapy concept
Original language description
Boron has been suggested to enhance the biological effectiveness of proton beams in the Bragg peak region via the p + 11B -> 3 alpha nuclear capture reaction. However, a number of groups have observed no such enhancement in vitro or questioned its proposed mechanism recently. To help elucidate this phenomenon, we irradiated DU145 prostate cancer or U-87 MG glioblastoma cells by clinical 190 MeV proton beams in plateau or Bragg peak regions with or without 10B or 11B isotopes added as sodium mercaptododecaborate (BSH). The results demonstrate that 11B but not 10B or other components of the BSH molecule enhance cell killing by proton beams. The enhancement occurs selectively in the Bragg peak region, is present for boron concentrations as low as 40 ppm, and is not due to secondary neutrons. The enhancement is likely initiated by proton-boron capture reactions producing three alpha particles, which are rare events occurring in a few cells only, and their effects are amplified by intercellular communication to a population-level response. The observed up to 2-3-fold reductions in survival levels upon the presence of boron for the studied prostate cancer or glioblastoma cells suggest promising clinical applications for these tumour types.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging

Project
<a href="/en/project/GA21-06451S" target="_blank" >GA21-06451S: Puzzling enhancement of proton-induced cellular damage by boron</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)