First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F18%3A00501235" target="_blank" >RIV/68378271:_____/18:00501235 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/s41598-018-19258-5" target="_blank" >http://dx.doi.org/10.1038/s41598-018-19258-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-018-19258-5" target="_blank" >10.1038/s41598-018-19258-5</a>

Result language

angličtina

Original language name

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

Original language description

Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET ( Linear Energy Transfer) C-12-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper C-12-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + B-11 -> 3 alpha reaction to generate high-LET alpha particles with a clinical proton beam.Boron-Neutron Capture Therapy (BNCT) uses B-10-enriched BSH for neutron irradiationtriggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10305 - Fluids and plasma physics (including surface physics)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

Jan

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

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UT code for WoS article

000422739300104

EID of the result in the Scopus database

2-s2.0-85040775433