Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F01%3A55010081" target="_blank" >RIV/61389013:_____/01:55010081 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy.

Original language description

RNase A unimer was conjugated with two N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, forming classic and starconjugates. Their antitumor effects were tested both in vitro and in vivo. Unlike the wild bovine pancreatic ribonuclease (RNase A), bothpolymer conjugates injected intraperitoneally or intravenously displayed a potent antitumor activity in nude mice bearing human melanoma. At the same time, their cytotoxic activity tested on various tumor cell lines was very low.

Czech name

—

Czech description

—

Type

D - Article in proceedings

CEP classification

ED - Physiology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings.

ISBN

—

ISSN

—

e-ISSN

—

Number of pages

2

Pages from-to

—

Publisher name

Controlled Release Society

Place of publication

San Diego

Event location

San Diego [US]

Event date

Jun 23, 2001

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

—