Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F02%3A21023018" target="_blank" >RIV/67985904:_____/02:21023018 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/02:00001972

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice.

Original language description

Bovine seminal ribonuclease(BS-RNase) is an antitumoral active enzyme exhibiting specific antitumoral action against a number of different cancer cell lines.However, its systemic use is limited by its pharmacokinetic properties and antigenicity.Therefore, it was conjugated to polyethylene glycol(PEG) chains to overcome these problems. In order to Investigate the antitumoral efficacy of BS-RNase-PEG 'In vivo', preliminary experiments on the effect of the conjugate on neuroblastoma growth in mice were performed in a UKF-NB-3 xenotransplantate model, demonstrating a drastically increased antitumoral activity of the conjugate compared to the free enzyme.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anti-Cancer Drugs

ISSN

0959-4973

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

N/A

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

149-154

UT code for WoS article

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EID of the result in the Scopus database

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