Effect of wheat leaf ribonuclease on tumor cells and tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F06%3A00017818" target="_blank" >RIV/60461373:22330/06:00017818 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/06:00042631 RIV/00216208:11110/06:00005261 RIV/00023736:_____/06:00006530 RIV/00216208:11310/06:12365
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effect of wheat leaf ribonuclease on tumor cells and tissues
Original language description
The antiproliferative and antitumor effect of wheat leaf ribonuclease (WLN-RNase) was tested in vitro on the human ML-2 cell line and in vivo on athymic nude mice bearing human melanoma tumors. The antiproliferative activity of this plant ribonuclease was negligible in comparison with bovine seminal ribonuclease (BS-RNase). However, in the experiments in vivo, a significant decrease of the tumor size was observed in the mice treated with WLN-RNase (27 kDa) compared to the control RNase A and PEG (polyethylenglycol). In nude mice injected intratumoraly with WLN-RNase the tumor size decreased from 100 percent in the control mice to 39 percent in treated mice. In the mice treated with PEG-conjugated WLN-RNase the tumor reduction was observed from 100 to 28 percent while in counterparts treated with PEG-conjugated BS-RNase the tumor inhibition was observed from 100 to 33 percent. Certain aspermatogenic and embryotoxic activity of WLN-RNase and BS-RNase also appeared but lower in comparison
Czech name
Vliv pšeničné ribonukleasy na buňku a tkáně tumoru
Czech description
Byl testován vliv rostliné ribonukleasy na myši nesoucí lidský melanom. Bylo pozorováno signifikantní zmenšení tumorů. Jedná se pravděpodobně o první studium rostliné ribonukleasy jako protinádorového léčiva in vivo.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Drugs
ISSN
0959-4973
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
815-823
UT code for WoS article
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EID of the result in the Scopus database
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