Antitumor and biological effects of black pine (Pinus nigra) pollen nuclease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F08%3A00021230" target="_blank" >RIV/60461373:22330/08:00021230 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/08:00321558 RIV/67985904:_____/08:00321558 RIV/00216208:11110/08:1925 RIV/00023736:_____/09:00008251

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Antitumor and biological effects of black pine (Pinus nigra) pollen nuclease

Original language description

The antitumor effect of black pine (Pinus nigra) pollen nuclease (PN) tested in vitro was negligible in comparison with bovine seminal ribonuclease (BS-RNase). However, in the experiments in vivo a significant decrease of the human melanoma tumor size was observed in the mice treated with this nuclease and also with the animal RNases and DNase I. In nude mice injected intratumoraly with PN (10?g/dose) the tumor size decreased from 100% in the control mice to 46% in treated mice whereas in counterparts treated with BS-RNase and DNase I the tumor growth was reduced a little more, however after ten times higher doses (100 and 80?g per dose). Certain aspermatogenic and embryotoxic activity as an expression of side effects of PN and comparative enzymes alsoappeared, but it was lower compared to the effect of bovine seminal ribonuclease. Immunogenicity of PN was significantly weaker in compaison with BS-RNase.The antibodies against black pine nuclease produced in the injected mice did not i

Czech name

Protinádorový a biologický účinek pylové nukleasy z borovice Pinus nigra

Czech description

Byl studován protinádorový a biologický účinek pylové nukleasy z borovice Pinus nigra.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA523%2F04%2F0755" target="_blank" >GA523/04/0755: Biological and antitumor effects of pancreatic ribonuclease A oligomers</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

2

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

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UT code for WoS article

000253229100013

EID of the result in the Scopus database

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