Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F02%3A55023136" target="_blank" >RIV/61389013:_____/02:55023136 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors.

Original language description

We have designed, synthesized, and evaluated new lysosomotropic (water-soluble) polymer-cathepsin K inhibitor conjugates. A potent selective cathepsin K inhibitor, 1,5-bis(N-benzyloxycarbonylleucyl)carbohydrazide, was modified to 1-(N-benzyloxycarbonylleucyl)-5-(phenylalanylleucyl)carbohydrazide to facilitate polymer conjugation. It was conjugated to the polymer chain termini of two watersoluble polymers alpha-methoxy poly(ethylene glycol) and semitelechelic poly[N-(2-hydroxypropyl)methacrylamide].

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/KSK4055109" target="_blank" >KSK4055109: Physics, chemistry and informatics for biological, ecological and medicinal applications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemistry

ISSN

0006-2960

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

28

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

8849-8859

UT code for WoS article

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EID of the result in the Scopus database

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