Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F02%3A55023337" target="_blank" >RIV/61389013:_____/02:55023337 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Bioconjugates of cathepsin K inhibitors with water/soluble polymers: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.
Original language description
We synthesized novel bioconjugates of cathepsin K inhibitor, 1-(N-benzyl-oxy-carbonylleucyl)-5-(phenylalanylleucyl)-carbo-hydrazide with a-methoxy poly(ethylene glycol), semitelechelic poly[N-(2-hydroxypropyl)-methacrylamide] and HPMA copolymers containing reactive side-chans. The inhibitory activity of macromolecular inhibitors for cysteine proteinases as well as their ability to inhibit cathepsin K activity in synovial fibroblasts were evaluated.
Czech name
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Czech description
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Project
<a href="/en/project/KSK4055109" target="_blank" >KSK4055109: Physics, chemistry and informatics for biological, ecological and medicinal applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Intelligent Drug Delivery Systems Better and Safer Therapy.
ISBN
975-491-126-6
ISSN
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e-ISSN
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Number of pages
2
Pages from-to
12-13
Publisher name
Hacettepe University Pharmacy Faculty
Place of publication
Istanbul
Event location
Istanbul [TR]
Event date
Sep 9, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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