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Antibody-targeted polymer-doxorubicin conjugates with enzyme or pH-controlled activation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F04%3A00101342" target="_blank" >RIV/61389013:_____/04:00101342 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Antibody-targeted polymer-doxorubicin conjugates with enzyme or pH-controlled activation

  • Original language description

    Various structures of polymer carriers and polymer drugs were synthesized and studied. Synthesis of antibody-targeted polymer-doxorubicin conjugates differing in the structure of the polymer carrier and the mechanism of drug release was elaborated. During the treatment with polymer-doxorubicin conjugates, the immune system of treated mice is activated and an effective long-term anti-tumor immunity is established. Antibody-targeted polymer drugs are thus promising candidates for effective cancer treatment.

  • Czech name

    Protilátkou cílené konjugáty polymer-doxorubicin s enzymem nebo pH kontrolovanou aktivací

  • Czech description

    Rozličné struktury polymerních nosičů u polymerních léčiv byly připraveny a studovány. Byla rozpracována syntéza protilátkou cílených konjugátů polymer-doxorubicin lišících se strukturou polymerního nosiče a mechanismem uvolnění léčiva. V průběhu léčby polymer-doxorubicinovými konjugáty je aktivován imunitní systém léčené myši a vzniká dlouhodobá protinádorová imunita. Protilátkou cílená polymerní léčiva tak jsou slibnými kandidáty pro účinnou léčbu rakoviny.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Congress Proceedings

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

  • Publisher name

    International Union of Pure and Applied Chemistry

  • Place of publication

    Paris

  • Event location

    Paris

  • Event date

    Jul 4, 2004

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article