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Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F08%3A00312213" target="_blank" >RIV/61389013:_____/08:00312213 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy

  • Original language description

    A passively targeted water-soluble polymer drug delivery system based on N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin and/or gemcitabine was designed for combined cancer therapy, taking advantage of both radiotherapeutical and chemotherapeutical effects of the drugs attached to the polymer carrier via biodegradable spacers. The syngeneic and radio- and chemoresistant Dunning AT1 rat prostate carcinoma was used as a tumour model

  • Czech name

    Pasivně směrovaná polymerní nanoléčiva pro radiochemoterapii nádorových onemocnění

  • Czech description

    Byl syntetizován pasivně směrovaný systém pro dopravu léčiv založený na vodorozpustných kopolymerech N-(2-hydroxypropyl)methakrylamidu obsahujících léčivo doxorubicin a nebo gemcitabin navázané přes biodegradovatelnou spojku pro kombinovanou radioterapiia chemoterapii nádorových onemocnění. Účinnost kombinované radio a chemoterapie byla testována na radio a chemoresistantním Dunning AT1 krysím karcinomu prostaty.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1M0505" target="_blank" >1M0505: Center of targeted therapeutic drugs</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    British Journal of Cancer

  • ISSN

    0007-0920

  • e-ISSN

  • Volume of the periodical

    99

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    259061800010

  • EID of the result in the Scopus database