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Adenovirus type 5 (Ad5) is sequestered and inactivated by binding to coxsackievirus and adenovirus receptor (CAR) and complement receptor 1 (CR1) on human erythrocytes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F08%3A00323764" target="_blank" >RIV/61389013:_____/08:00323764 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adenovirus type 5 (Ad5) is sequestered and inactivated by binding to coxsackievirus and adenovirus receptor (CAR) and complement receptor 1 (CR1) on human erythrocytes

  • Original language description

    Human erythrocytes presents Coxsackie virus-adenovirus receptor providing an Ad5 sequestration mechanism that protects them against systemic virus infection but a virus binds via the fiber protein of Ad5 leading to close juxtaposition with the erythrocyte membrane. ?Stealthing of Ad5 using hydrophilic polymers enable circumvention of these natural virus traps.

  • Czech name

    Adenovirus typu 5 (Ad5) je oddělen a deaktiviván vazbou na receptor coxsackie a adenoviru (CAR) a receptor 1 komplementu (CR1) lidských erythrocytů

  • Czech description

    Lidské erythrocyty presentují Coxsackie virus-adenovirus receptor poskytující adenoviru (Ad5) oddělovací mechanizmus, který je chrání proti virální infekci, ale virus se váže prostřednictvím vláknitého proteinu, což vede k těsnému spojení s erythrocytovou membránou. Povrchová modifikace Ad5 pomocí hydrofilních polymerů umožní obejití této přirozené virální pasti.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Human Gene Therapy

  • ISBN

  • ISSN

    1043-0342

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

  • Publisher name

    Mary Ann Liebert Inc

  • Place of publication

    New Rochelle

  • Event location

    Brugge

  • Event date

    Nov 13, 2008

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000260633700357