Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00384590" target="_blank" >RIV/61389013:_____/12:00384590 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2217/NNM.12.50" target="_blank" >http://dx.doi.org/10.2217/NNM.12.50</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/NNM.12.50" target="_blank" >10.2217/NNM.12.50</a>
Alternative languages
Result language
angličtina
Original language name
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer
Original language description
Intravenous delivery of therapeutic virus particles remains a major goal for virotherapy of metastatic cancer. Polymer coating of adenovirus type 5 (Ad5) can combine with predosing strategies or Kupffer cell ablation to achieve systemic kinetics with a half-life >60 min, allowing ready access to peripheral tumors. Polymer coating wild-type Ad5 in this way is known to decrease hepatic toxicity, increasing the dose of virus particles that can be safely administered. Using polymer-coating technology to deliver a replicating Ad5 systemically, virus replication and transgene expression was almost totally confined to tumor tissues, giving a much improved therapeutic index compared with uncoated virus, and complete control of human HepG2 tumor xenografts.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/IAAX00500803" target="_blank" >IAAX00500803: Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomedicine
ISSN
1743-5889
e-ISSN
—
Volume of the periodical
7
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
1683-1695
UT code for WoS article
000311329700013
EID of the result in the Scopus database
—