Bioactive support for cell cultivation and potential grafting. Part1. Surface modification of 2-hydroxyethyl methacrylate hydrogels for avidin immobilization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F11%3A00359861" target="_blank" >RIV/61389013:_____/11:00359861 - isvavai.cz</a>

Result on the web

<a href="http://www.e-polymers.org/journal/abstract.cfm?abstract_Id=3616" target="_blank" >http://www.e-polymers.org/journal/abstract.cfm?abstract_Id=3616</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Bioactive support for cell cultivation and potential grafting. Part1. Surface modification of 2-hydroxyethyl methacrylate hydrogels for avidin immobilization

Original language description

Synthetic hydrogels are often used in biomedical applications as many of them are compatible with living tissue and moreover they meet the most criteria for artificial tissue properties. To enhance the cell adhesion and proliferation, it is desirable tomodify the polymer surface by some bioactive compounds (e.g. saccharides, proteins). In this work, firstly carboxyl-enriched hydrogels were prepared by various methods: by copolymerization of 2 hydroxyethyl methacrylate with methacrylic acid, by hydrolysis or oxidation of poly(2 hydroxyethyl methacrylate). Subsequently, avidin was immobilized to the modified hydrogel surfaces either electrostatically through dissociated carboxylic groups or covalently through carboxylic groups activated by N-hydroxysuccinimide. Preliminary biological tests showed that hydrogels with immobilized avidin provides better adhesion and proliferation of keratinocytes compared to supports without avidin.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

—

Project

<a href="/en/project/1QS400500558" target="_blank" >1QS400500558: Bioactive support for cell cultivation and grafting</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

E-Polymers

ISSN

1618-7229

e-ISSN

—

Volume of the periodical

-

Issue of the periodical within the volume

43

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

1-17

UT code for WoS article

000290474600001

EID of the result in the Scopus database

—