Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumor efficacy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F11%3A00363631" target="_blank" >RIV/61389013:_____/11:00363631 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/11:00363631
Result on the web
<a href="http://dx.doi.org/10.1016/j.jconrel.2011.06.015" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2011.06.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2011.06.015" target="_blank" >10.1016/j.jconrel.2011.06.015</a>

Result language
angličtina
Original language name
Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumor efficacy
Original language description
New biodegradable star polymer?doxorubicin conjugates designed for passive tumor targeting were investigated, and their synthesis, physico-chemical characterization, drug release, biodegradation, biodistribution and in vivo anti-tumor efficacy are described. In the conjugates, the core formed by poly(amidoamine) (PAMAM) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers bearing doxorubicin (Dox) attached by hydrazone bonds, which enabled intracellular pH-controlled drug release. The described synthesis facilitated the preparation of biodegradable polymer conjugates in a broad range of molecular weights (200?1000 g/mol) while still maintaining low polydispersity ( 1.7). The polymer grafts were attached to thedendrimers through either stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the high-molecular-weight polymer carrier to excretable products.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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