Novel star HPMA-based polymer conjugates for passive targeting to solid tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F11%3A00367005" target="_blank" >RIV/61389013:_____/11:00367005 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/11:00367005
Result on the web
<a href="http://dx.doi.org/10.3109/1061186X.2011.622402" target="_blank" >http://dx.doi.org/10.3109/1061186X.2011.622402</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/1061186X.2011.622402" target="_blank" >10.3109/1061186X.2011.622402</a>
Alternative languages
Result language
angličtina
Original language name
Novel star HPMA-based polymer conjugates for passive targeting to solid tumors
Original language description
Novel star polymer-doxorubicin conjugates designed for passive tumor targeting have been developed and their potential for treatment of cancer has been investigated. In the present study the synthesis, physico-chemical characterization, drug release, bio-distribution and preliminary data of in vivo efficacy of the conjugates are described. In the water-soluble conjugates the core of a molecule formed by poly(amido amine) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide copolymers bearing doxorubicin attached by hydrazone bonds enabling intracellular pH-controlled hydrolytic drug release, or by GFLG sequence susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of polymer conjugates in a broad range of molecular weights. The star polymer-Dox conjugates showed significantly higher anti-tumor activity in vivo than Dox HCl or its linear or graft polymer conjugates.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Drug Targeting
ISSN
1061-186X
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
874-889
UT code for WoS article
000297057100003
EID of the result in the Scopus database
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