pH-triggered block copolymer micelles based on a pH-responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate]) inner core and a PEO (poly(ethylene oxide)) outer shell as a potential tool for the cancer therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F11%3A00364286" target="_blank" >RIV/61389013:_____/11:00364286 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C1SM05992K" target="_blank" >http://dx.doi.org/10.1039/C1SM05992K</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C1SM05992K" target="_blank" >10.1039/C1SM05992K</a>

Result language
angličtina
Original language name
pH-triggered block copolymer micelles based on a pH-responsive PDPA (poly[2-(diisopropylamino)ethyl methacrylate]) inner core and a PEO (poly(ethylene oxide)) outer shell as a potential tool for the cancer therapy
Original language description
The potential of a novel pH-triggered block copolymer as a promising drug delivery platform for the cancer therapy has been explored. The block copolymer poly(ethylene oxide)-b-poly(glycerol monomethacrylate)-b-poly[2-(diisopropylamino)ethyl methacrylate] self-assembled into highly regular spherical micelles whose structure was characterized in detail by light scattering, small angle X-ray scattering, fluorescence spectroscopy and transmission electron microscopy. The micellar size (42 nm) and micellarmolecular weight were found to be in the range to avoid renal clearance providing a long blood circulation time. The pH-responsive core could be loaded with the poorly water-soluble anti-cancer drug paclitaxel (PTX) with encapsulation efficiency 70%. Therelease experiments evidenced that the micellar dissociation might be triggered at the slightly acid tumoral extracellular environments.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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