Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F11%3A00365161" target="_blank" >RIV/61389013:_____/11:00365161 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/pola.24930" target="_blank" >http://dx.doi.org/10.1002/pola.24930</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/pola.24930" target="_blank" >10.1002/pola.24930</a>

Result language
angličtina
Original language name
Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions
Original language description
Magnetic poly(N-propargylacrylamide) (PPRAAm) microspheres were prepared by the precipitation polymerization of N-propargylacrylamide in a toluene/propan-2-ol medium in the presence of magnetic nanoparticles. The effects of polymerization parameters, including the polarity of the medium, polymerization temperature, the concentration of monomer, and the amount of magnetite in the polymerization feed, were examined. The microspheres were characterized in terms of their morphology, size, distribution, andiron content using TEM, SEM and AAS. As expected, Oleic acid-coated Fe3O4 nanoparticles contributed to the stabilization of the magnetic microspheres. Alkyne groups in magnetic PPRAAm microspheres were detected by IR. Microspheres were used as the anchorto enable a click?? reaction with an azido-end-functionalized model peptide (radiolabeled azidopentanoyl-GGGRGDSGGGY(125I)-NH2) and 4-azidophenylalanine using a Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction in water.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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