Overcoming cellular multidrug resistance using classical nanomedicine formulations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00372588" target="_blank" >RIV/61389013:_____/12:00372588 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejps.2011.08.028" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2011.08.028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2011.08.028" target="_blank" >10.1016/j.ejps.2011.08.028</a>
Alternative languages
Result language
angličtina
Original language name
Overcoming cellular multidrug resistance using classical nanomedicine formulations
Original language description
In the present report, we have set out to evaluate the ability of classical (and pharmacologically inactive) carrier materials to overcome MDR. To this end, four different drug-sensitive and drug-resistant cancer cell lines were treated with increasing concentrations of free doxorubicin, of polymer-bound doxorubicin, of micellar doxorubicin and of liposomal doxorubicin, and resistance indices (IC50 in resistant cells/IC50 in sensitive cells) were determined. In addition, the cellular uptake of the fourformulations was evaluated using fluorescence microscopy. It was found that the carrier materials did manage to overcome MDR to some extent, but that the overall benefit was quite small; only for polymer-bound doxorubicin in A431 cells, a significant (4-fold) reduction in the resistance index was observed. These findings indicate that the ability of classical nanomedicines to overcome cellular MDR should not be overestimated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/IAA400500806" target="_blank" >IAA400500806: Branched and hyperbranched polymer carriers of drugs for local therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmaceutical Sciences
ISSN
0928-0987
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
421-428
UT code for WoS article
000300861700005
EID of the result in the Scopus database
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