Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00378727" target="_blank" >RIV/61389013:_____/12:00378727 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/c2nr30623a" target="_blank" >http://dx.doi.org/10.1039/c2nr30623a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c2nr30623a" target="_blank" >10.1039/c2nr30623a</a>

Result language
angličtina
Original language name
Light scattering evidence of selective protein fouling on biocompatible block copolymer micelles
Original language description
Selective protein fouling on block copolymer micelles with well-known potential for tumour-targeting drug delivery was evidenced by using dynamic light scattering measurements. The stability and interaction of block copolymer micelles with model proteins(BSA, IgG, lysozyme and CytC) is reported for systems featuring a hydrophobic (poly[2-(diisopropylamino)-ethyl methacrylate]) (PDPA) core and hydrophilic coronas comprising poly(ethylene oxide)/poly(glycerol monomethacrylate) (PEOb-PG2MA) or poly[2-(methacryloyloxy)ethyl phosphorylcholine] (PMPC). The results revealed that protein size and hydrophilic chain density play important roles in the observed interactions. The successful protein-repellent characteristic of these nanoparticles is attributed toa high hydrophilic surface chain density (>0.1 chains per nm2) and to the length of the hydrophilic chains.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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