Hepatocyte growth on polycapronolactone and 2-hydroxyethylmethacrylate nanofiber sheets enhanced by bone marrow-derived mesenchymal stromal cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00420631" target="_blank" >RIV/61389013:_____/13:00420631 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/13:00420631 RIV/61383082:_____/13:0029

Result on the web

<a href="http://dx.doi.org/10.5754/hge11948" target="_blank" >http://dx.doi.org/10.5754/hge11948</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5754/hge11948" target="_blank" >10.5754/hge11948</a>

Result language

angličtina

Original language name

Hepatocyte growth on polycapronolactone and 2-hydroxyethylmethacrylate nanofiber sheets enhanced by bone marrow-derived mesenchymal stromal cells

Original language description

The development of Bioartificial Liver Assist Devices (BLADs), intended for the therapy of chronic and fulminant liver failure, is one of the most important tasks in the area of tissue engineering. The primary objective of our research was to examine theinteractions of cell cultures (hepatocytes, bone marrow mesenchynal stromal cell mixed cultures) with nanofiber-based materials, which can be utilized as carriers for high density cultures, and to test the possibility of creating a polarized hepatocyteculture on a nanofiber layer., separating two compartments with a different composition of the cultivation medium (simulating the capillary and bile compartments of the hepatic tissue). The results reported demonstrate that nonwoven nanofiber layers area suitable biocompatible support for functional, hepatocyte cultures and can be utilized in a laboratory bioreactor; mesenchymal stromal cells from bone marrow may be utilized in order to enhance hepatocyte functionality on the nanofiber

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hepato-Gastroenterology

ISSN

0172-6390

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

125

Country of publishing house

GR - GREECE

Number of pages

8

Pages from-to

1156-1163

UT code for WoS article

000330327700039

EID of the result in the Scopus database

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