Hepatocyte Growth on Polycapronolactones and 2-Hydroxyethylmethacrylate Nanofiber Sheets Enhanced by Bone Marrow-Derived Mesenchymal Stromal Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209730" target="_blank" >RIV/00216208:11130/13:10209730 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24620/13:#0000257
Result on the web
<a href="http://dx.doi.org/10.5754/hge11948" target="_blank" >http://dx.doi.org/10.5754/hge11948</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5754/hge11948" target="_blank" >10.5754/hge11948</a>
Alternative languages
Result language
angličtina
Original language name
Hepatocyte Growth on Polycapronolactones and 2-Hydroxyethylmethacrylate Nanofiber Sheets Enhanced by Bone Marrow-Derived Mesenchymal Stromal Cells
Original language description
Background/Aims: The development of hepatocyte-based Bioartificial Liver Assist Devices, intended for the therapy of chronic and fulminant liver failure, is one of the important tasks in the area of tissue engineering. New advances in the development ofsemipermeable non-woven nanofiber biomaterials and the co-cultivation of bone marrow mesenchymal stromal cells (BMSC) and hepatocytes could be utilized in order to maintain hepatocyte cultures in these devices. Methodology: We have compared rat hepatocyte growth on nanofiber biomaterials from different polymers, 2-hydroxyethylmethacrylate (HEMA) and ethoxyethylmethacrylate (EOEMA) copolymers, polyurethane (PUR), chitosan and polycapronolactone (PCL) spun from different solvent mixtures. Results: In allcases the adhesion of hepatocytes to nanofibers was significantly better/stronger than to unstructured polymer surfaces; coating the nanofibers with collagen did not increase cell adhesion. We found the best hepatocyte adhesion on HEMA/EO
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hepato-Gastroenterology
ISSN
0172-6390
e-ISSN
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Volume of the periodical
60
Issue of the periodical within the volume
125
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
1156-1163
UT code for WoS article
000330327700039
EID of the result in the Scopus database
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