Non-Fouling Biodegradable Poly(epsilon-caprolactone) Nanofibers for Tissue Engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F16%3A00310400" target="_blank" >RIV/68407700:21340/16:00310400 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/16:00454747 RIV/61389013:_____/16:00454747
Result on the web
<a href="https://doi.org/10.1002/mabi.201500252" target="_blank" >https://doi.org/10.1002/mabi.201500252</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.201500252" target="_blank" >10.1002/mabi.201500252</a>
Alternative languages
Result language
angličtina
Original language name
Non-Fouling Biodegradable Poly(epsilon-caprolactone) Nanofibers for Tissue Engineering
Original language description
Poly(ε-caprolactone) (PCL) nanofibers are very attractive materials for tissue engineering (TE) due to their degradability and structural similarity to the extracellular matrix (ECM). However, upon exposure to biological media, their surface is rapidly fouled by proteins and cells, which may lead to inflammation and foreign body reaction. In this study, an approach for the modification of PCL nanofibers to prevent protein fouling from biological fluids and subsequent cell adhesion is introduced. A biomimetic polydopamine (PDA) layer was deposited on the surface of the PCL nanofibers and four types of antifouling polymer brushes were grown by surface-initiated atom transfer radical polymerization (SI-ATRP) from initiator moieties covalently attached to the PDA layer. Cell adhesion was assessed with mouse embryonic fibroblasts (MEFs). MEFs rapidly adhered and formed cell-matrix adhesions (CMAs) with PCL and PCL-PDA nanofibers. Importantly, the nanofibers modified with antifouling polymer brushes were able to suppress non-specific protein adsorption and thereby cell adhesion. Four antifouling polymer brushes are grown from biodegradable poly(ε-caprolactone) nanofibers without impairing their unique architecture. The nanofibers are challenged with mouse embryonic fibroblasts. Fibroblasts are repelled from the nanofibers coated with brushes while the cells could rapidly adhere and form cell-matrix adhesions on pristine nanofibers. The nanofibers modified with protein repellent brushes are able to suppress cell adhesion.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
1616-5195
Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
83-94
UT code for WoS article
000368642300008
EID of the result in the Scopus database
2-s2.0-84954290374