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Non-fouling biodegradable poly(.epsilon.-caprolactone) nanofibers for tissue engineering

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F16%3A00454747" target="_blank" >RIV/68378271:_____/16:00454747 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/16:00454747 RIV/68407700:21340/16:00310400

  • Result on the web

    <a href="http://dx.doi.org/10.1002/mabi.201500252" target="_blank" >http://dx.doi.org/10.1002/mabi.201500252</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/mabi.201500252" target="_blank" >10.1002/mabi.201500252</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Non-fouling biodegradable poly(.epsilon.-caprolactone) nanofibers for tissue engineering

  • Original language description

    Poly(?-caprolactone) (PCL) nanofibers are very attractive materials for tissue engineering (TE) due to their degradability and structural similarity to the extracellular matrix (ECM). However, upon exposure to biological media, their surface is rapidly fouled by proteins and cells, which may lead to inflammation and foreign body reaction. In this study, an approach for the modification of PCL nanofibers to prevent protein fouling from biological fluids and subsequent cell adhesion is introduced. A biomimetic polydopamine (PDA) layer was deposited on the surface of the PCL nanofibers and four types of antifouling polymer brushes were grown by surface-initiated atom transfer radical polymerization (SI-ATRP) from initiator moieties covalently attached tothe PDA layer. Cell adhesion was assessed with mouse embryonic fibroblasts (MEFs). MEFs rapidly adhered and formed cell?matrix adhesions (CMAs) with PCL and PCL-PDA nanofibers. Importantly, the nanofibers modified with antifouling polymer

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BM - Solid-state physics and magnetism

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Macromolecular Bioscience

  • ISSN

    1616-5187

  • e-ISSN

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    12

  • Pages from-to

    83-94

  • UT code for WoS article

    000368642300008

  • EID of the result in the Scopus database

    2-s2.0-84954290374