Non-fouling biodegradable poly(.epsilon.-caprolactone) nanofibers for tissue engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F16%3A00454747" target="_blank" >RIV/68378271:_____/16:00454747 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/16:00454747 RIV/68407700:21340/16:00310400
Result on the web
<a href="http://dx.doi.org/10.1002/mabi.201500252" target="_blank" >http://dx.doi.org/10.1002/mabi.201500252</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.201500252" target="_blank" >10.1002/mabi.201500252</a>
Alternative languages
Result language
angličtina
Original language name
Non-fouling biodegradable poly(.epsilon.-caprolactone) nanofibers for tissue engineering
Original language description
Poly(?-caprolactone) (PCL) nanofibers are very attractive materials for tissue engineering (TE) due to their degradability and structural similarity to the extracellular matrix (ECM). However, upon exposure to biological media, their surface is rapidly fouled by proteins and cells, which may lead to inflammation and foreign body reaction. In this study, an approach for the modification of PCL nanofibers to prevent protein fouling from biological fluids and subsequent cell adhesion is introduced. A biomimetic polydopamine (PDA) layer was deposited on the surface of the PCL nanofibers and four types of antifouling polymer brushes were grown by surface-initiated atom transfer radical polymerization (SI-ATRP) from initiator moieties covalently attached tothe PDA layer. Cell adhesion was assessed with mouse embryonic fibroblasts (MEFs). MEFs rapidly adhered and formed cell?matrix adhesions (CMAs) with PCL and PCL-PDA nanofibers. Importantly, the nanofibers modified with antifouling polymer
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BM - Solid-state physics and magnetism
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
83-94
UT code for WoS article
000368642300008
EID of the result in the Scopus database
2-s2.0-84954290374