Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00558694" target="_blank" >RIV/61389013:_____/22:00558694 - isvavai.cz</a>
Alternative codes found
RIV/67985882:_____/22:00558694 RIV/00216208:11310/22:10453812
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2022/py/d2py00478j" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/py/d2py00478j</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D2PY00478J" target="_blank" >10.1039/D2PY00478J</a>
Alternative languages
Result language
angličtina
Original language name
Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”
Original language description
Antifouling polymer brushes are widely utilized in biomedical applications to prevent non-specific interactions with biological fluids. They consist of surface-tethered polymer chains and are commonly formed when the chains are “grafted to” (GT) a surface by chemisorption or “grafted from” (GF) a surface in a surface-initiated polymerization. Although the antifouling polymer brushes have been studied for years, an accurate comparison between the GT and GF methods in terms of the ability of the prepared brushes to resist fouling has not been established yet. In this study, we investigate physical and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes synthesized by GT and GF methods using reversible addition–fragmentation chain-transfer (RAFT) polymerization. Using size exclusion chromatography and single-molecule force spectroscopy, we are able to ensure that grafted polymer chains in the layers prepared by both methods have comparable composition and molar mass. Thus, we attribute the differences in fouling resistance and physical properties of the polymer layers to the physical conformation of the chains achieved by the selected grafting method. While both types of poly(HPMA) brushes are shown to substantially reduce fouling from blood plasma, the GF polymer brushes suppress fouling by an order of magnitude better than the GT polymer brushes. The observed difference in the antifouling performance is related to the much higher grafting density that can be achieved in the GF method. This study highlights the importance of the selection of the grafting method for achieving a high antifouling performance.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer Chemistry
ISSN
1759-9954
e-ISSN
1759-9962
Volume of the periodical
13
Issue of the periodical within the volume
25
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
3815-3826
UT code for WoS article
000811977700001
EID of the result in the Scopus database
2-s2.0-85132353699