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Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F22%3A00558694" target="_blank" >RIV/61389013:_____/22:00558694 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985882:_____/22:00558694 RIV/00216208:11310/22:10453812

  • Result on the web

    <a href="https://pubs.rsc.org/en/content/articlelanding/2022/py/d2py00478j" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/py/d2py00478j</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1039/D2PY00478J" target="_blank" >10.1039/D2PY00478J</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”

  • Original language description

    Antifouling polymer brushes are widely utilized in biomedical applications to prevent non-specific interactions with biological fluids. They consist of surface-tethered polymer chains and are commonly formed when the chains are “grafted to” (GT) a surface by chemisorption or “grafted from” (GF) a surface in a surface-initiated polymerization. Although the antifouling polymer brushes have been studied for years, an accurate comparison between the GT and GF methods in terms of the ability of the prepared brushes to resist fouling has not been established yet. In this study, we investigate physical and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)) brushes synthesized by GT and GF methods using reversible addition–fragmentation chain-transfer (RAFT) polymerization. Using size exclusion chromatography and single-molecule force spectroscopy, we are able to ensure that grafted polymer chains in the layers prepared by both methods have comparable composition and molar mass. Thus, we attribute the differences in fouling resistance and physical properties of the polymer layers to the physical conformation of the chains achieved by the selected grafting method. While both types of poly(HPMA) brushes are shown to substantially reduce fouling from blood plasma, the GF polymer brushes suppress fouling by an order of magnitude better than the GT polymer brushes. The observed difference in the antifouling performance is related to the much higher grafting density that can be achieved in the GF method. This study highlights the importance of the selection of the grafting method for achieving a high antifouling performance.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polymer Chemistry

  • ISSN

    1759-9954

  • e-ISSN

    1759-9962

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    25

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    3815-3826

  • UT code for WoS article

    000811977700001

  • EID of the result in the Scopus database

    2-s2.0-85132353699