Structural diversity of solid dispersions of acetylsalicylic acid as seen by solid-state NMR

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00426114" target="_blank" >RIV/61389013:_____/14:00426114 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/mp400495h" target="_blank" >http://dx.doi.org/10.1021/mp400495h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/mp400495h" target="_blank" >10.1021/mp400495h</a>

Result language

angličtina

Original language name

Structural diversity of solid dispersions of acetylsalicylic acid as seen by solid-state NMR

Original language description

Solid dispersions of active pharmaceutical ingredients are of increasing interest due to their versatile use. In the present study polyvinylpyrrolidone (PVP), poly[N-(2-hydroxypropyl)-metacrylamide] (pHPMA), poly(2-ethyl-2-oxazoline) (PEOx), and polyethylene glycol (PEG), each in three Mw, were used to demonstrate structural diversity of solid dispersions. Acetylsalicylic acid (ASA) was used as a model drug. The obtained structural data confirmed that the type of solid dispersion can be primarily controlled by the chemical constitutions of the applied polymers, while the molecular weight of the polymers had no detectable impact. The molecular structure of the prepared dispersions was characterized using solid-state NMR, wide-angle X-ray scattering (WAXS), and differential scanning calorimetry (DSC). By applying various 1H?13C and 1H?1H correlation experiments combined with T1(1H) and T1?(1H) relaxation data, the extent of the molecular mixing was determined over a wide range of distanc

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GPP106%2F11%2FP426" target="_blank" >GPP106/11/P426: Enhancement of bioavailability of insoluble pharmaceutical substances by the action of polymeric matrix</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MOLECULAR PHARMACEUTICS

ISSN

1543-8384

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

516-530

UT code for WoS article

000330812500015

EID of the result in the Scopus database

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