Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00427396" target="_blank" >RIV/61389013:_____/14:00427396 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jconrel.2014.03.007" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2014.03.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2014.03.007" target="_blank" >10.1016/j.jconrel.2014.03.007</a>

Result language
angličtina
Original language name
Characterizing EPR-mediated passive drug targeting using contrast-enhanced functional ultrasound imaging
Original language description
The Enhanced Permeability and Retention (EPR) effect is extensively used in drug delivery research. Taking into account that EPR is a highly variable phenomenon, we have here set out to evaluate if contrast-enhanced functional ultrasound (ceUS) imaging can be employed to characterize EPR-mediated passive drug targeting to tumors. Using standard fluorescence molecular tomography (FMT) and two different protocols for hybrid computed tomography-fluorescence molecular tomography (CT-FMT), the tumor accumulation of a 10 nm-sized near-infrared-fluorophore-labeled polymeric drug carrier (pHPMA-Dy750) was evaluated in CT26 tumor-bearing mice. In the same set of animals, two different ceUS techniques (2D MIOT and 3D B-mode imaging) were employed to assess tumorvascularization. Subsequently, the degree of tumor vascularization was correlated with the degree of EPR-mediated drug targeting. Depending on the optical imaging protocol used, the tumor accumulation of the polymeric drug carrier ranged
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
<a href="/en/project/GCP207%2F12%2FJ030" target="_blank" >GCP207/12/J030: STIMULI RESPONSIVE NANOCARRIERS FOR HIGHLY EFFICIENT POLYMER THERAPEUTICS</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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