Noninvasive optical imaging of nanomedicine biodistribution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00388377" target="_blank" >RIV/61389013:_____/13:00388377 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1021/nn303955n" target="_blank" >http://dx.doi.org/10.1021/nn303955n</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/nn303955n" target="_blank" >10.1021/nn303955n</a>

Result language

angličtina

Original language name

Noninvasive optical imaging of nanomedicine biodistribution

Original language description

Nanomedicines are sub-micrometer-sized carrier materials designed to improve the biodistribution of i.v. administered (chemo-) therapeutic agents. In recent years, ever more efforts in the nanomedicine field have employed optical imaging (OI) techniquesto monitor biodistribution and target site accumulation. Thus far, however, the longitudinal assessment of nanomedicine biodistribution using OI has been impossible, due to limited light penetration (in the case of 2D fluorescence reflectance imaging; FRI) and to the inability to accurately allocate fluorescent signals to nonsuperficial organs (in the case of 3D fluorescence molecular tomography; FMT). Using a combination of high-resolution microcomputed tomography (?CT) and FMT, we have here set out toestablish a hybrid imaging protocol for noninvasively visualizing and quantifying the accumulation of near-infrared fluorophore-labeled nanomedicines in tissues other than superficial tumors. To this end, HPMA-based polymeric drug carrie

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP301%2F11%2F0325" target="_blank" >GAP301/11/0325: Depletion of T regulatory cells without need of anti-CD25 mAb for effective chemoimmunotherapy by HPMA-based polymeric drugs and IL-2 immunocomplexes</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Nano

ISSN

1936-0851

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

252-262

UT code for WoS article

000314082800029

EID of the result in the Scopus database

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