Novel poly(ethylene oxide monomethyl ether)-b-poly(.epsilon.-caprolactone) diblock copolymers containing a pH-acid labile ketal group as a block linkage

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00428455" target="_blank" >RIV/61389013:_____/14:00428455 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C4PY00114A" target="_blank" >http://dx.doi.org/10.1039/C4PY00114A</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C4PY00114A" target="_blank" >10.1039/C4PY00114A</a>

Result language
angličtina
Original language name
Novel poly(ethylene oxide monomethyl ether)-b-poly(.epsilon.-caprolactone) diblock copolymers containing a pH-acid labile ketal group as a block linkage
Original language description
A new biocompatible and biodegradable diblock copolymer that contains a specific acid-labile degradable linkage (acyclic ketal group) between the hydrophobic poly(?-caprolactone) (PCL) and the hydrophilic poly(ethylene oxide monomethyl ether) (MPEO) blocks is described herein. A multi-step synthetic method that combines carbodiimide chemistry, a ?click reaction and ring-opening polymerization (ROP) was employed to successfully produce a series of MPEO-b-PCL diblock copolymers (herein referred to as MPEO44-b-PCL17 and MPEO44-b-PCL44). 2-{[2-(2-Azidoethoxy)propan-2-yl]}ethan-1-ol was obtained as a linker between the two blocks through a three-step synthetic approach. Furthermore, a newly developed ?-methoxy-?-hydroxy-poly(ethylene oxide) that contains anacid-labile ketal linkage was designed as a macroinitiator via a ?click reaction for the sequential controlled ring-opening polymerization of ?-CL. The newly obtained compounds (precursors, macromer, macroinitiator and final diblock copo
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)