Novel thermosensitive telechelic PEGs with antioxidant activity: synthesis, molecular properties and conformational behaviour

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00431359" target="_blank" >RIV/61389013:_____/14:00431359 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C4RA06978A" target="_blank" >http://dx.doi.org/10.1039/C4RA06978A</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C4RA06978A" target="_blank" >10.1039/C4RA06978A</a>

Result language
angličtina
Original language name
Novel thermosensitive telechelic PEGs with antioxidant activity: synthesis, molecular properties and conformational behaviour
Original language description
We report on the synthesis and solution properties of novel tailor-made polymer conjugates, which are highly compelling for biomedical applications due to their antioxidant activity and the potential to fine-tune their thermosensitive properties. These conjugates consist of polyethylene glycol (PEG) polymers containing antioxidant moieties, namely 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate or 2-benzamido-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylate, as end groups that differ in activity and hydrophobicity. It was shown that all of the synthesized conjugates have low critical solution temperatures (LCSTs) characteristic of type II polymers on a phase diagram. By simply varying the PEG molecular weight, the solution properties, including the LCST value, could be easily tuned across a broad temperature range of 20?90 °C, providing an ideal method for the creation of thermosensitive polymers. It was also established that the LCST value and the polymer conjugate conformation depend on
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP208%2F10%2F1600" target="_blank" >GAP208/10/1600: Polymeric particles and nanostructured materials stabilized by surface active molecules</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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