Multi-responsive polymer micelles as ellipticine delivery carriers for cancer therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00441424" target="_blank" >RIV/61389013:_____/15:00441424 - isvavai.cz</a>

Result on the web

<a href="http://ar.iiarjournals.org/content/35/2/753.abstract?sid=96cfc41a-f1c4-4ef8-9ce9-ab1de350a742" target="_blank" >http://ar.iiarjournals.org/content/35/2/753.abstract?sid=96cfc41a-f1c4-4ef8-9ce9-ab1de350a742</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Multi-responsive polymer micelles as ellipticine delivery carriers for cancer therapy

Original language description

In the present study, we describe the synthesis and physicochemical properties of a novel pH- and thermoresponsive micellar drug delivery system for an anticancer ellipticinium derivative based on the triblock copolymer poly(ethylene oxide)-block-[tert-butylacrylamide-co-6-(N-methacryloylamino)hexanoic acid hydrazide]-block-poly(ethylene oxide). The system was designed to meet the basic criteria required for drug carrier systems, namely, solubility in water (overcoming the insolubility of ellipticine),satisfactory drug loading, particle size suitable for an efficient enhanced permeability and retention effect and adequate stability in blood plasma (pH 7.4) followed by rapid drug release in tumors or tumor cell endosomes (pH <6.5). The copolymer in theform of a unimer can be eliminated by kidneys because the weight-average molecular weight of 21 kDa is sufficiently below the renal threshold. The half-life of drug release in a pH 5.0 buffer solution (pH of a late endosome) was 45 h, bu

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

2

Country of publishing house

GR - GREECE

Number of pages

5

Pages from-to

753-757

UT code for WoS article

000349598600018

EID of the result in the Scopus database

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