Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F15%3A00448089" target="_blank" >RIV/61389013:_____/15:00448089 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/C5TB01193K" target="_blank" >http://dx.doi.org/10.1039/C5TB01193K</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C5TB01193K" target="_blank" >10.1039/C5TB01193K</a>

Result language

angličtina

Original language name

Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines

Original language description

Multidrug delivery devices are designed to take advantage of the synergistic effects of anticancer agents in combination therapies. Here we report novel liquid crystalline self-assembled nanocarriers enhancing the activity of the phytochemical anticanceragent baicalin (BAI) in combination with Brucea javanica oil (BJO), which ensures safe formulations for clinical applications. Small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) evidenced the multicompartment,sponge-type nano-organization of the blank and multidrug-loaded liquid crystalline carriers. Physico-chemical stability of the sponge nanoparticles was achieved through PEGylation of the lipid membranes, which make up the drug nanocarriers. The proposedgreen nanotechnology for nanocarrier preparation by supramolecular self-assembly provided a multidrug encapsulation efficiency as high as 75%. The apoptosis study with the human lung carcinoma cell line A549 demonstrated improved efficacy

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

—

Project

<a href="/en/project/GC15-10527J" target="_blank" >GC15-10527J: Spherical „horse in vacuum“ or applicable micelles? Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Volume of the periodical

3

Issue of the periodical within the volume

39

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

7734-7744

UT code for WoS article

000362350600011

EID of the result in the Scopus database

2-s2.0-84942852277