Efficient condensation of DNA into environmentally responsive polyplexes produced from block catiomers carrying amine or diamine groups
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00456133" target="_blank" >RIV/61389013:_____/16:00456133 - isvavai.cz</a>
Alternative codes found
RIV/61388955:_____/16:00456133
Result on the web
<a href="http://dx.doi.org/10.1021/acs.langmuir.5b04080" target="_blank" >http://dx.doi.org/10.1021/acs.langmuir.5b04080</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.langmuir.5b04080" target="_blank" >10.1021/acs.langmuir.5b04080</a>
Alternative languages
Result language
angličtina
Original language name
Efficient condensation of DNA into environmentally responsive polyplexes produced from block catiomers carrying amine or diamine groups
Original language description
The intracellular delivery of nucleic acids requires a vector system as they cannot diffuse across lipid membranes. Although polymeric transfecting agents have been extensively investigated, none of the proposed gene delivery vehicles fulfill all of the requirements needed for an effective therapy, namely, the ability to bind and compact DNA into polyplexes, stability in the serum environment, endosome-disrupting capacity, efficient intracellular DNA release, and low toxicity. The challenges are mainly attributed to conflicting properties such as stability vs efficient DNA release and toxicity vs efficient endosome-disrupting capacity. Accordingly, investigations aimed at safe and efficient therapies are still essential to achieving gene therapy clinical success.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/LH14292" target="_blank" >LH14292: Crosstalk between pH and temperature responsivity: How it can be used for polymer nanoparticulate systems for biomedical applications?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Langmuir
ISSN
0743-7463
e-ISSN
—
Volume of the periodical
32
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
577-586
UT code for WoS article
000368563700023
EID of the result in the Scopus database
2-s2.0-84955509554