iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00458826" target="_blank" >RIV/61389013:_____/16:00458826 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/16:00458826 RIV/00216208:11310/16:10324101 RIV/00216208:11110/16:10324101
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/anie.201508642/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/anie.201508642/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201508642" target="_blank" >10.1002/anie.201508642</a>
Alternative languages
Result language
angličtina
Original language name
iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties
Original language description
Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability, and difficulty of chemical modification. The design and preparation of synthetic polymer conjugates capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, immunocytochemistry, and immunoprecipitation is reported. The conjugates, named " iBodies", consist of an HPMA copolymer decorated with low-molecular-weight compounds that function as targeting ligands, affinity anchors, and imaging probes. We prepared specific conjugates targeting several proteins with known ligands and used these iBodies for enzyme inhibition, protein isolation, immobilization, quantification, and live-cell imaging. Our data indicate that this highly modular and versatile polymer system can be used to produce inexpensive and stable antibody substitutes directed toward virtually any protein of interest with a known ligand.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
2356-2360
UT code for WoS article
000369970500007
EID of the result in the Scopus database
2-s2.0-84957850230