Targeting myeloid cells and modulation of their function by fully synthetic antibody mimetics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00618341" target="_blank" >RIV/61388963:_____/23:00618341 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Targeting myeloid cells and modulation of their function by fully synthetic antibody mimetics
Original language description
This study explores the selective targeting of CD64-expressing cells using iBodies, synthetic antibody mimetics conjugated to HPMA polymers. The conjugation significantly improves the binding affinity of Ligand L1, enhancing the specificity and efficacy of iBodies. Anti-CD64 iBodies demonstrated high specificity for monocytes and macrophages, confirmed through flow cytometry and confocal microscopy. Furthermore, cytotoxic iBodies selectively eliminated M2 macrophages while sparing M1 macrophages. These findings suggest that iBodies have strong potential for use in cancer immunotherapy by modulating immune responses and targeting tumor-associated macrophages.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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