Synthesis and solution properties of PCL-b-PHPMA diblock copolymers containing stable nitroxyl radicals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00462673" target="_blank" >RIV/61389013:_____/16:00462673 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10327751
Result on the web
<a href="http://dx.doi.org/10.1021/acs.macromol.6b01187" target="_blank" >http://dx.doi.org/10.1021/acs.macromol.6b01187</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.macromol.6b01187" target="_blank" >10.1021/acs.macromol.6b01187</a>

Result language
angličtina
Original language name
Synthesis and solution properties of PCL-b-PHPMA diblock copolymers containing stable nitroxyl radicals
Original language description
This work focuses on the synthesis and the aqueous solution properties of novel amphiphilic PCL-b-PHPMA diblock copolymers possessing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) stable radicals covalently conjugated to the hydrophobic poly(ε-caprolactone) (PCL) block. A new synthetic approach (a four-step pathway) combining ring-opening polymerization (ROP), carbodiimide chemistry (DCC method), a reversible addition–fragmentation chain transfer (RAFT) polymerization technique, and finally chemical oxidation was employed to successfully produce a series of TEMPO-containing PCL-b-PHPMA diblock copolymers for the first time. EPR spectroscopy was applied to verify successful oxidation of the synthesized diblock copolymers and to investigate the dynamics of the polymer chains before and after micellization. The diblock copolymers self-assembled in PBS solution into spherical radical-containing nanoparticles (RNPs), which were characterized by 1H NMR spectroscopy, dynamic (DLS), static (SLS) light scattering, and cryo-transmission electron microscopy (cryo-TEM). These novel RNPs could find applications, e.g., as drug delivery systems and for the treatment of oxidative stress injuries.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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